Azerbaijan National Academy of Science

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Gadirova Leyla Baghdad gizi
Place of birth Baku, Azerbaijan 
Date of birth 1983 
Education Baku State University   
Scientific degree PhD in biology  
Title Associate professor 
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Human and Animal Physiology

The impact of prenatal hypoxia on the activity of phosphate-dependent glutaminase and glutamate dehydrogenase in the rat brain in postnatal ontogenesis

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Basic scientific achievements The effect of hypoxia at different periods of prenatal development on the activity of glutamate metabolism enzymes in tissues and mitochondrial fractions of different brain regions of rat in postnatal ontogenesis was studied. Changes in the activity of glutaminase in different brain structures, may be due to the activation of both glutamate- and GABAergic systems, and changes in the activity of glutamate dehydrogenase could be associated with the supply of intermediates in the citrate cycle in nerve cells and could be a protective and adaptive response of the brain. 
Names of scientific works 1. Activity of phosphate-dependent glutaminase in the brain of rats exposed to prenatal hypoxia during organogenesis // Bulletin of Experimental Biology and Medicine. New-York: Springer, 2015 Dec; 160(2): p.187-189.

2. Особенности изменения активности Na+,K+-АТФазы и Mg2+-ATФазы в различных структурах мозга крысят, перенесших гипоксию в период органогенеза // Ж. Асимметрия, Journal of asymmetry, Москва, 2017, т.11, №1, с.61-67.

3. Постнатальные изменения глутаминазной активности в мозге крыс, перенесших гипоксию в плодном периоде пренатального развития // Вестник Тверского Государственного Университета. Серия биология и экология, Тверь, Россия, 2010, вып.18, с.49-53.

4. Effect of prenatal hypoxia on the enzymes of glutamate metabolism in one-month-old rat brain // “Stress and Development: Neurophysiological and Neurochemical Aspects” International Scientific Conference dedicated to the 90-th Anniversary of Azerbaijani National Leader Heydar Aliyev. Baku, May 7-8, 2013, p.7-8.

5. Effect of prenatal hypoxia on activity of glutamine synthetase and glutamate dehydrogenase in rat brain // 2nd Intern. Interdiscip. Conference on “Modern problems in systemic regulation of physiological functions”, Bodrum, Turkey, 2012, p.179-180.

Membership with international and foreign scientific organizations Member of the Society of Physiologists of Azerbaijan
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Main place of work and its address Institute of Physiology named after Academician Abdulla Garayev of ANAS, 2 Sharifzadeh Str., AZ1100 Baku
Position Senior researcher 
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