Azerbaijan National Academy of Science

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Gasimov Karim Guli oglu
Place of birth Saatli of Azerbaijan Republic   
Date of birth 30 November, 1958 
Education Azerbaijan (present Baku) State University, Faculty of biology 
Scientific degree Doctor of Biological Scioences 
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The regulation of cAMP phosfodiesteraze activity by red light and calmoduline in maize seedlings
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Molekulyar biologiya

Molecular-Genetic characteristics of signal transduction in eukaryotes: G-proteins and JOINTLES-1transcription factor. 
Total number of printed scientific publications:

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Basic scientific achievements

1. The study of the organization and genetic control of cellular signaling systems in higher plants revealed that: The enzymes of cyclic nucleotides (cAMP and cGMP), cyclases and phosphodiesterases strongly react to the influence of the monochromatic red (660 nm) and far-red (730 nm) light absorbed by phytochrome;

The nonhydrolyzable analogue of GTP  Gpp(NH)p influences the activity of cAMP exchange enzymes isolated from illuminated by red-lit etiolated maize and sorghum seedlings. At the same time, enzymes from un-illuminated seedlings do not react to the action of Gpp(NH)p.

2. The study of the role of GPR motif proteins in the exchange of guanine nucleotides using recombinant proteins revealed: All GPR (GoLoco) motif-containing proteins preferentially interact only with G-proteins Gαi class (Gαi1, Gαo, Gαt). GPR-motif proteins exhibit the same interaction pattern with Gαi1 in the following sequence of affinity: Gαi1GDP Gαi1GDPAlF4- Gαi1GTP S;

Upon binding to GiαGDP, GPR proteins compete with Gβγ. GPR proteins inhibit GDP dissociation, and with the inhibition of the GDP/GTP exchange, they can inhibit GPCR-activation of G proteins.

3. The study of molecular mechanisms for the transmission of extracellular signals using the rhodopsin receptor and the GPR protein transducin revealed the following features: Gαt interacts with C2, C3 and C4 intracellular loops. The residues of R147, F148 and to a lesser degree C140, K141 in the C2 loop, as well as the residues T229, V230, S240, and T242, T243, Q244 in the C3 loop participate in the interaction with Gαt. The juxtamembrane regions of loops are more important for R*/Gt binding than the regions in the central regions of the loops.

The residues N310, K311, F313, and M317 of the C4 loop are important for Gαt activation, while N310 and K311 are important for post-translational protein folding, and F313 and M317 for interaction with Gt.

4. As a transcriptional regulation of plant differentiation during development, the role of MADS domain transcription factor - JOINTLESS1 - in the formation of the abscission zone formation in flowers and leaves of tomato plants was studied.

Analysis of the signals obtained from the mutant and chimeric tomato plants shows that the programming and coordination of the differentiation of cells and tissues in the apical meristem occurs in the third (L3) layer, which coordinates cell division and in the first (L1) and second (L2) layers that differentiate the organs.

5. As transcriptional regulation of plant responses to abiotic stresses of the environment, the role of WRKY superfamily members in plant responses to abiotic stresses such as elevated salt and water deficiency has been studied. It was shown that the transcription factor of tomato plant WRKY33 is the main factor that regulates plant tolerance to abiotic stress, such as water deficiency and increased salinity.

Names of scientific works

1. К.Г. Гасымов, Л.А. Наджафова Ген SlWRKY способствует толерантности растений тоиата к солевому и водному стрессам. Физиология Растений и Генетика, 2014, Т. 46, сс. 385-394

2. Gasimov K.G. GTP-binding proteins are potential messengers for photosygnal transduction in high plants. Proceedings of the 15th International Congress on Photosynthesis, Advanced Topics in Science and Technology in China. Press and Springer, 2013, pp. 331-334.

3. Gasimov K.G. Two Splice forms of JOINTLESS-1 are involved in abscission zone formation in tomato plants. Applied and Computational Mathematics, 2010, v. 9, pp. 50-55.

4. Natochin M, Gasimov KG, Moussaif M, Artemyev NO. Rhodopsin determinants for transducin activation: a gain-of-function approach. Journal Biol. Chem. 2003, V. 278(39), pp. 37574-81.

5. M. Natochin, K.G. Gasimov, and N.O. Artemyev, A GPR-Protein Interaction Surface of Giα: Implications for the Mechanism of GDP-Release Inhibition. Biochemistry, 2002, 41, 258-265.

6. M. Natochin, K.G. Gasimov, and N.O. Artemyev: Inhibition of GDP/GTP Exchange on G Subunits by Proteins Containing G-Protein Regulatory Motifs. Biochemistry, 2001, 40, 5322-5328.

7. Gasimov KG. Participation of multiple forms of light regulated Adenylyl Cyclase from S.Bicolor seedlings in plant photosygnal transduction chain. Proc. of Azerbaijan Nat. Acad., Biological Sciences, 2002, v. 57 (5-6), pp 253-263.

8. Fedenko E.P., Gasumov K.G., S.R. Agamalova Light-dependent response of cAMP phosphodiesterase to gibberellins. BIOLOGY BULLETIN-Russian Academy of Sciences C/C of Izvestiia-RAN Seriia Biologicheskaia, 1999, 26, 508-510

Membership with international and foreign scientific organizations  
Pedagogical activity

2011-2015 - Baku State University, faculity of biology

2014-2016 -  Lankaran State University
Other activities  
Awards and prizes  
Main place of work and its address

Institute of Biophysics, ANAS, 117 Z.Khalilov Str., Baku, AZ1141 


Deputy director on scientific affair;

PI of the lab “Molecular and cellular biochemistry” 
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