Azerbaijan National Academy of Sciences

Scientific report of the director of the Institute of Biophysics, Corresponding Member of ANAS Oktay Gasimov on "Multidisciplinary study of lung cancer and neurodegenerative amyloid diseases: primary outcomes and prospects" was listened at the meeting of the Presidium of the Azerbaijan National Academy of Sciences, held at the Azerbaijan Medical University on July 17.

The scientist said that oncology and neurodegenerative diseases are one of the top priorities of modern bio medicine. Genetic, stress and other factors play an important role in these diseases. There is a great need for the introduction of new innovative multidisciplinary approaches to addressing the medical and social problems created by these multidimensional diseases, he said.

The speaker emphasized the importance of application of new screening methods that can reveal the initial stage of the illness. He emphasized that this approach is important both for the survival of patients and the likelihood of their healing and economic efficiency.

O. Gasimov said that the temperature-dependent dynamics of the membrane of healthy and malignant tumor cells differ sharply from each other. At present, artificial local hyperthermia is used to increase the effectiveness of the chemical therapy of malignant tumors, as well as to improve the radio sensitivity of tissues during radiotherapy.

Academicians Rasim Alguliev, Dilgam Tagiyev, Irada Huseynova, Ahliman Amiraslanov, Vagif Farzaliyev, correspondent member of ANAS Ramiz Aliguliyev, Professor Habil Muradov and others made speeches and proposals after the report was discussed.

The report was positively assessed by the Presidium. The Institute of Biophysics of ANAS together with the National Center of Oncology of the Ministry of Health improved the number of lung cancer classification by increasing the volume of database and creation of an economically effective screening method for lung cancer and other assignments. Given the multidimensional process of managing the transcription status of the human genome, it was decided to work on the creation of a material and technical basis of cellular technologies at the Institute of Biophysics to continue the work of cancer related illnesses, to develop the direction of individual medicine, taking into account the important role of mutations in oncology and neurodegenerative amyloid diseases. received.

The speaker said that multidisciplinary research on morphology of malignant tumor cells is rapidly expanding. He emphasized that in the tumor tissue, the cellular environment is poorly acidic, while the normal cellular surface is weakly alkaline.

O. Gasimov said that work on identifying and specifying the principal genetic factors causing the formation of malignant tumor cells on the basis of an integrated biological approach, mathematical modeling of malignant tumors, prediction and the establishment of appropriate diagnostic systems. He pointed out that the new TSShm method and other computer programs created by the Biotechnology Laboratory for promoter search in the human genome show at least 1 potential 2-promoter (2-IP) for 650 of the 702 genes known to be cancerous. The speaker added that important results in this direction were published in reputable international magazines (BBA-Proteins and Proteomics, 2018, Journal of Spectroscopy, 2018, Macromol.Chem.Phys, 2019).

Academicians Rasim Alguliev, Dilgam Tagiyev, Irada Huseynova, Ahliman Amiraslanov, Vagif Farzaliyev, correspondent member of ANAS Ramiz Aliguliyev, Professor Habil Muradov and others made speeches and proposals after the report was discussed.

The report was positively assessed by the Presidium. The Institute of Biophysics of ANAS together with the National Center of Oncology of the Ministry of Health improved the number of lung cancer classification by increasing the volume of database and creation of an economically effective screening method for lung cancer and other assignments.

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